Sanofi logo

Information about latent TB infection (LTBI)

Latent TB infection, or LTBI, is the name for the stage where TB bacteria have entered the body, but are not yet active. This latent infection does not cause any symptoms. If they become active and start growing, then Latent TB turns into active TB disease.

Most people with LTBI are unaware of the danger that may have already quietly settled in them 2

You don't have any TB infection

Healthy

You don't have any TB infection

some alt

Breathing in bacteria from person with active TB

some title

LTBI

You do not feel sick and you have no symptoms

some alt

Risk of progression

some title

Active TB

LTBI can become active TB, making you ill and risking infection for those you live with

TB vs LTBI: What’s the difference? What are the symptoms?

This video will give you an overview of the differences between TB and LTBI.
You will learn about the symptoms of TB and ways to prevent active infection and treat TB if it does happen.

 Meet John  and learn  his story!
Symptoms of TB
00:01
Chapter 1: Symptoms of TB
How dangerous is TB
00:22
Chapter 2: How dangerous is TB
How LTBI can turn into TB
00:38
Chapter 3: How LTBI can turn into TB
How LTBI and TB can be treated
01:22
Chapter 4: How LTBI and TB can be treated
people people people people people people people people people people

10% of people with LTBI develop active TB during their lifetime 3

For some people the risk is much higher than 10% 2

These people have a high risk of LTBI becoming active tuberculosis infection. To see why, and what can be done, check out this video.

Meet Jon and his family
00:06
Chapter 1: Meet Jon and his family
Learn more about LTBI
00:29
Chapter 2: Learn more about LTBI
TB and Immune system
01:19
Chapter 3: TB and Immune system
Who are at high risk?
01:34
Chapter 4: Who are at high risk?
Persons living with HIV
02:12
Chapter 5: Persons living with HIV
some alt
02:50
Chapter 6: Symptoms of TB
 High-Risk  population  for TB

TB is the leading cause of death among people living with HIV, causing more than one third of all AIDS-related deaths.3 Adults and adolescents living with HIV should receive TB preventive treatment as part of a comprehensive package of HIV care.4
People with HIV should ask their practitioner about TB preventative therapy as part of comprehensive package for HIV care.

TREAT HIV. TREAT LTBI

For your information:
  • HIV (human immunodeficiency virus) is a virus that damages the cells in your immune system and weakens your ability to fight everyday infections and disease.
  • AIDS (acquired immune deficiency syndrome) is the name used to describe a number of potentially life-threatening infections and illnesses that happen when your immune system has been severely damaged by the HIV virus.

How do I know if I have LTBI?

LTBI does not have any symptoms, and you cannot know if you have it unless you have a positive skin or blood test. You don't have to live with the worry of not knowing whether you have latent TB, ask your doctor to arrange a test.

There are options to treat LTBI

If your test is positive and you are diagnosed with LTBI, don't worry there are several treatment options.

The treatment needs to:
  • effectively treat LTBI with limited side effects
  • be convenient to take
  • be easy for you to complete
Treatment regimen Length of Treatment Schedule How many intakes
6-9H 6-9 months Once a day 180-270
4R 4 months Once a day 120
3-4RH 3-4 months Once a day 90-120
3HP 3 months Once a week 12
1HP 28 days Once a day 28
6H: 300 mg of isoniazid, 9H: 300 mg of isoniazid, 3HP: 900 mg of isoniazid + 900 mg of rifapentine, 3R: 600 mg of rifampin, 3HR: 600 mg of rifampin + 300 mg of isoniazid, 4R: 600 mg of rifampin, 4HR: 600 mg of rifampin + 300 mg of isoniazid, 1HP: 600 mg of rifapentine + 300 mg of isoniazid.

TAKE ACTION TODAY

SEEK TREATMENT BEFORE IT IS TOO LATE

Now is the time to treat LTBI and avoid sickness
  • LTBI is not an active disease, but it can awaken when you least expect it and you can get sick with TB at any moment
  • Rather than waiting for symptoms of TB to appear, it is best to prevent its occurrence altogether, by identifying the disease when it is LTBI and treating it effectively
  • Completing your treatment prevents you from becoming sick with active TB in the future 1

Talk to your doctor today about LTBI

  • What is the definition of LTBI, or latent tuberculosis (TB) infection?

    Latent TB infection, or LTBI, is the name for the stage where TB bacteria have entered the body, but are not yet active. The word latent means that something is hidden or sleeping. Latent TB infection does not cause any symptoms. If the TB bacteria become active and start growing, then Latent TB turns into active TB disease. You can find out more about how that happens here.

  • What are the symptoms of LTBI, or latent tuberculosis (TB) infection ?

    People with LTBI do not feel sick. They do not have any symptoms. They have been infected with the tuberculosis bacteria called Mycobacterium tuberculosis, but they do not have TB disease.

  • Can LTBI, or latent tuberculosis (TB) infection, become active ?

    Without treatment, about 1 out of 10 people with LTBI will develop active TB in their lifetime. For some people this risk is higher than others. The people with high risk include children, people living with HIV or AIDS, people living in close contact with someone who has active TB, and people with other conditions that lead to a weak immune system.

  • Is LTBI, or latent tuberculosis (TB) infection, dangerous ?

    LTBI in itself is not dangerous, but there is a danger that it turns into active TB. Most people who have LTBI do not even know it. That’s why it could be considered a hidden danger. If someone has a high risk of TB, he or she should be tested for LTBI and treated, if needed. Talk to your healthcare professional about being tested for LTBI.

  • Is LTBI, or latent tuberculosis (TB) infection, contagious ?

    People with LTBI are not contagious. They cannot spread TB infection to others.

  • Are there treatments for LTBI, or latent tuberculosis (TB) infection? Can LTBI be cured ?

    Taking treatment for LTBI is much easier than treating TB once it is active.